A-196, CAS [[1982372-88-2]]

Produktübersicht

• Artikelname: A-196, CAS [[1982372-88-2]]
• Artikelnummer: FBM-10-4018
• Hersteller Artikelnummer: 10-4018
• Alternativnummer: FBM-10-4018-5MG,FBM-10-4018-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

SUV420H1/H2 lysine methyltransferase inhibitor

Produkteigenschaften

• Molekulargewicht: 359.25
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1982372-88-2]
• Formel: C18H16Cl2N4

Anwendungsbeschreibung

• Anwendungsbeschreibung: A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.