Chemical Name: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
SUV420H1/H2 lysine methyltransferase inhibitor
Molecular Weight:
359.25
Purity:
98% by TLC NMR (Conforms)
Form:
White solid
CAS Number:
[1982372-88-2]
Formula:
C18H16Cl2N4
Application Notes:
A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
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