Chemical Name: (E)-N-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide. Alternate Names: HCI-2509
LSD1 inhibitor
Molekulargewicht:
437.90
Reinheit:
98% by HPLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[1423715-09-6]
Formel:
C19H20ClN3O5S
Anwendungsbeschreibung:
Potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A).1 It is inactive against the closely related flavin enzymes MAO A,B as well as lactate dehydrogenase, several CYPs and hERG. LSD1 regulates the balance between self-renewal and differentiation of stem cells and is highly expressed in various cancers.2-6 SP2509 promotes autophagy in neuroblastoma cells.7
10-4019
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