EED-226, CAS [[2083627-02-3]]

Produktübersicht

• Artikelname: EED-226, CAS [[2083627-02-3]]
• Artikelnummer: FBM-10-4021
• Hersteller Artikelnummer: 10-4021
• Alternativnummer: FBM-10-4021-5MG, FBM-10-4021-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine

Produktbeschreibung

PRC2 methyltransferase inhibitor

Produkteigenschaften

• Molekulargewicht: 369.40
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [2083627-02-3]
• Formel: C17H15N5O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: EED-226 is a potent (IC50 = 23.4 nM) and selective allosteric inhibitor of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 It caused drastic proliferation inhibition in lymphoma cells with EZH2 mutations and caused shrinkage and slower tumor growth in mice using a subcutaneous xenograft model of Karpas422.