EED-226, CAS [[2083627-02-3]]

Product Overview

• Article Name: EED-226, CAS [[2083627-02-3]]
• Biozol Catalog Number: FBM-10-4021
• Supplier Catalog Number: 10-4021
• Alternative Catalog Number: FBM-10-4021-5MG, FBM-10-4021-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine

Product Description

PRC2 methyltransferase inhibitor

Product Properties

• Molecular Weight: 369.40
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2083627-02-3]
• Formula: C17H15N5O3S

Application Notes

• Application Notes: EED-226 is a potent (IC50 = 23.4 nM) and selective allosteric inhibitor of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 It caused drastic proliferation inhibition in lymphoma cells with EZH2 mutations and caused shrinkage and slower tumor growth in mice using a subcutaneous xenograft model of Karpas422.