iBAP-II, CAS [[1013813-81-4]]

Produktübersicht

• Artikelname: iBAP-II, CAS [[1013813-81-4]]
• Artikelnummer: FBM-10-4038
• Hersteller Artikelnummer: 10-4038
• Alternativnummer: FBM-10-4038-5MG,FBM-10-4038-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

BAP1 deubiquitinase inhibitor

Produkteigenschaften

• Molekulargewicht: 308.33
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1013813-81-4]
• Formel: C18H16N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 µg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.