iBAP-II, CAS [[1013813-81-4]]

Product Overview

• Article Name: iBAP-II, CAS [[1013813-81-4]]
• Biozol Catalog Number: FBM-10-4038
• Supplier Catalog Number: 10-4038
• Alternative Catalog Number: FBM-10-4038-5MG, FBM-10-4038-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-(8-Nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-yl)phenol

Product Description

BAP1 deubiquitinase inhibitor

Product Properties

• Molecular Weight: 308.33
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [1013813-81-4]
• Formula: C18H16N2O3

Application Notes

• Application Notes: Inhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 µg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.