TETi76 ester, CAS [[1451750-73-4]]

Produktübersicht

• Artikelname: TETi76 ester, CAS [[1451750-73-4]]
• Artikelnummer: FBM-10-4041
• Hersteller Artikelnummer: 10-4041
• Alternativnummer: FBM-10-4041-10MG,FBM-10-4041-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: Diethyl 2-hydroxy-4-methylenepentanedioate

Produktbeschreibung

TET inhibitor

Produkteigenschaften

• Molekulargewicht: 216.23
• Reinheit: >98% TLC, NMR (Conforms)
• Formulierung: Colorless oil
• CAS Nummer: [1451750-73-4]
• Formel: C10H16O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 µM, TET2 = 9.4 µM, TET3 = 8.8 µM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms - TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.