TETi76 ester, CAS [[1451750-73-4]]

Product Overview

• Article Name: TETi76 ester, CAS [[1451750-73-4]]
• Biozol Catalog Number: FBM-10-4041
• Supplier Catalog Number: 10-4041
• Alternative Catalog Number: FBM-10-4041-10MG, FBM-10-4041-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Diethyl 2-hydroxy-4-methylenepentanedioate

Product Description

TET inhibitor

Product Properties

• Molecular Weight: 216.23
• Purity: >98% TLC, NMR (Conforms)
• Form: Colorless oil
• CAS Number: [1451750-73-4]
• Formula: C10H16O5

Application Notes

• Application Notes: Cell permeable inhibitor of TET dioxygenases (IC50s: TET1 = 1.5 µM, TET2 = 9.4 µM, TET3 = 8.8 µM), indirect (via cytosine hydroxymethylation) erasers of DNA methylation.1,2 TET2 is frequently mutated in myeloid neoplasms - TET2 inhibition with TETi76 restricted clonal outgrowth and induced apoptosis of TET2 mutants but not normal hematopoietic precursor cells in vitro and in vivo.