SR1078, CAS [[1246525-60-9]]

Produktübersicht

• Artikelname: SR1078, CAS [[1246525-60-9]]
• Artikelnummer: FBM-10-4066
• Hersteller Artikelnummer: 10-4066
• Alternativnummer: FBM-10-4066-10MG,FBM-10-4066-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

ROR agonist

Produkteigenschaften

• Molekulargewicht: 431.26
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1246525-60-9]
• Formel: C17H10F9NO2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Agonist of the orphan nuclear receptors RORalpha and RORgamma.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORalpha restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5