SR1078, CAS [[1246525-60-9]]

Product Overview

• Article Name: SR1078, CAS [[1246525-60-9]]
• Biozol Catalog Number: FBM-10-4066
• Supplier Catalog Number: 10-4066
• Alternative Catalog Number: FBM-10-4066-10MG, FBM-10-4066-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(trifluoromethyl)benzamide

Product Description

ROR agonist

Product Properties

• Molecular Weight: 431.26
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1246525-60-9]
• Formula: C17H10F9NO2

Application Notes

• Application Notes: Agonist of the orphan nuclear receptors RORalpha and RORgamma.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORalpha restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5