UNC9435, CAS [[3091640-25-1]]

Produktübersicht

• Artikelname: UNC9435, CAS [[3091640-25-1]]
• Artikelnummer: FBM-10-4082
• Hersteller Artikelnummer: 10-4082
• Alternativnummer: FBM-10-4082-5MG,FBM-10-4082-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: trans-4-((2-((3-Chlorophenyl)amino)-5-(1-(cyclopentylmethyl)-piperidin-4-yl)pyrimidine-4-yl)amino)cyclohexan-1-ol

Produktbeschreibung

Dual TYRO3/MERTK inhibitor

Produkteigenschaften

• Molekulargewicht: 520.54
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [3091640-25-1]
• Formel: C27H38ClN5OHCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: UNC9435 is a potent dual inhibitor of TYRO3 (IC50 = 3.7 nM) and MERTK (IC50 = 1.1 nM), TAM family kinases with roles in oncogenesis and innate immunity.1 Displays 46-fold selectivity over the TAM kinase AXL and 120-fold selectivity over FLT3. It inhibited colony formation in H1650 and H1975 NSCLC cell lines and inhibited efferocytosis.

Bilder

10-4082