UNC9435, CAS [[3091640-25-1]]

Product Overview

• Article Name: UNC9435, CAS [[3091640-25-1]]
• Biozol Catalog Number: FBM-10-4082
• Supplier Catalog Number: 10-4082
• Alternative Catalog Number: FBM-10-4082-5MG, FBM-10-4082-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: trans-4-((2-((3-Chlorophenyl)amino)-5-(1-(cyclopentylmethyl)-piperidin-4-yl)pyrimidine-4-yl)amino)cyclohexan-1-ol

Product Description

Dual TYRO3/MERTK inhibitor

Product Properties

• Molecular Weight: 520.54
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [3091640-25-1]
• Formula: C27H38ClN5OHCl

Application Notes

• Application Notes: UNC9435 is a potent dual inhibitor of TYRO3 (IC50 = 3.7 nM) and MERTK (IC50 = 1.1 nM), TAM family kinases with roles in oncogenesis and innate immunity.1 Displays 46-fold selectivity over the TAM kinase AXL and 120-fold selectivity over FLT3. It inhibited colony formation in H1650 and H1975 NSCLC cell lines and inhibited efferocytosis.