Imaradenant, CAS [[1321514-06-0]]

Produktübersicht

• Artikelname: Imaradenant, CAS [[1321514-06-0]]
• Artikelnummer: FBM-10-4095
• Hersteller Artikelnummer: 10-4095
• Alternativnummer: FBM-10-4095-5MG, FBM-10-4095-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-(2-Chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine. Alternate Names: AZD4635

Produktbeschreibung

A2AR antagonist

Produkteigenschaften

• Molekulargewicht: 315.74
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [1321514-06-0]
• Formel: C15H11ClFN3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Imaradenant is a potent and selective A2AR antagonist (IC50 = 0.79 nM 0.1 µM adenosine).1 It restores T cell function and tumor antigen cross-presentation by CD103+ dendritic cells resulting in enhanced antitumor immunity. Imaradenant reduced tumor load in a murine model of multiple myeloma in combination with anti-CD73 therapy.2 It displayed efficacy in combination with PD-1 inhibitors against prostate cancer.3,4 AZD4635 increased the infiltration of cytotoxic T cells and decreased infiltration of immunosuppressive cells to increase the efficacy of PARP inhibitors in an ovarian cancer model.5