Imaradenant, CAS [[1321514-06-0]]

Product Overview

• Article Name: Imaradenant, CAS [[1321514-06-0]]
• Biozol Catalog Number: FBM-10-4095
• Supplier Catalog Number: 10-4095
• Alternative Catalog Number: FBM-10-4095-5MG, FBM-10-4095-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-(2-Chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine. Alternate Names: AZD4635

Product Description

A2AR antagonist

Product Properties

• Molecular Weight: 315.74
• Purity: >98% by HPLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [1321514-06-0]
• Formula: C15H11ClFN3

Application Notes

• Application Notes: Imaradenant is a potent and selective A2AR antagonist (IC50 = 0.79 nM 0.1 µM adenosine).1 It restores T cell function and tumor antigen cross-presentation by CD103+ dendritic cells resulting in enhanced antitumor immunity. Imaradenant reduced tumor load in a murine model of multiple myeloma in combination with anti-CD73 therapy.2 It displayed efficacy in combination with PD-1 inhibitors against prostate cancer.3,4 AZD4635 increased the infiltration of cytotoxic T cells and decreased infiltration of immunosuppressive cells to increase the efficacy of PARP inhibitors in an ovarian cancer model.5