N6022, CAS [[1208315-24-5]]

Produktübersicht

• Artikelname: N6022, CAS [[1208315-24-5]]
• Artikelnummer: FBM-10-4103
• Hersteller Artikelnummer: 10-4103
• Alternativnummer: FBM-10-4103-5MG, FBM-10-4103-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

Produktbeschreibung

S-Nitrosogluthione reductase inhibitor

Produkteigenschaften

• Molekulargewicht: 414.46
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1208315-24-5]
• Formel: C24H22N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: N6022 is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) - IC50 = 20 nM1, 8 nM2. It demonstrated significant efficacy in a mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis) via selective inhibition of pro-inflammatory CD4+ cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+ cells (TH2/Treg) without causing lymphopenia.3