N6022, CAS [[1208315-24-5]]

Product Overview

• Article Name: N6022, CAS [[1208315-24-5]]
• Biozol Catalog Number: FBM-10-4103
• Supplier Catalog Number: 10-4103
• Alternative Catalog Number: FBM-10-4103-5MG,FBM-10-4103-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

S-Nitrosogluthione reductase inhibitor

Product Properties

• Molecular Weight: 414.46
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1208315-24-5]
• Formula: C24H22N4O3

Application Notes

• Application Notes: N6022 is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) - IC50 = 20 nM1, 8 nM2. It demonstrated significant efficacy in a mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis) via selective inhibition of pro-inflammatory CD4+ cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+ cells (TH2/Treg) without causing lymphopenia.3