AZD7648, CAS [[2230820-11-6]]

Produktübersicht

• Artikelname: AZD7648, CAS [[2230820-11-6]]
• Artikelnummer: FBM-10-4108
• Hersteller Artikelnummer: 10-4108
• Alternativnummer: FBM-10-4108-5MG, FBM-10-4108-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-Methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridine-6-yl)amino]-9-(oxan-4-yl)purin-8-one

Produktbeschreibung

DNA-PK inhibitor/CRISPR enhancer

Produkteigenschaften

• Molekulargewicht: 380.41
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2230820-11-6]
• Formel: C18H20N8O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2, cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.