AZD7648, CAS [[2230820-11-6]]

Product Overview

• Article Name: AZD7648, CAS [[2230820-11-6]]
• Biozol Catalog Number: FBM-10-4108
• Supplier Catalog Number: 10-4108
• Alternative Catalog Number: FBM-10-4108-5MG, FBM-10-4108-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 7-Methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridine-6-yl)amino]-9-(oxan-4-yl)purin-8-one

Product Description

DNA-PK inhibitor/CRISPR enhancer

Product Properties

• Molecular Weight: 380.41
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [2230820-11-6]
• Formula: C18H20N8O2

Application Notes

• Application Notes: AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2, cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.