Avutometinib, CAS [[946128-88-7]]

Produktübersicht

• Artikelname: Avutometinib, CAS [[946128-88-7]]
• Artikelnummer: FBM-10-4112
• Hersteller Artikelnummer: 10-4112
• Alternativnummer: FBM-10-4112-5MG,FBM-10-4112-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one. Alternate Names: RO5126766, CH5126766

Produktbeschreibung

Dual MEK/RAF inhibitor

Produkteigenschaften

• Molekulargewicht: 471.46
• Reinheit: >98% by HPLC (NMR Conforms)
• Formulierung: White solid
• CAS Nummer: [946128-88-7]
• Formel: C21H18FN5O5S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Avutometinib is a dual MEK/RAF inhibitor (IC50s: MEK = 160 nM, CRAF = 56 nM, BRAF = 19 nM, BRAF V600E = 8nM).1 It directly inhibits unphosphorylated MEK without causing induction of MEK phosphorylation by RAF. The avutemetinib-MEK adduct is a dominant-negative inhibitor of RAF, stabilizing the MEK/RAF complex and locking in an inactive form. Avutometinib displayed efficacy across multiple RAS-mutated cancer cell lines and an SK-MEL-2 xenograft model.2 It displayed synergistic effects with eribulin against triple-negative breast cancer cell lines.3 Avutometinib also displayed efficacy in combination with the FAK inhibitor Defactinib in KRAS-mutated NSCLC cells.4

Bilder

10-4112