Avutometinib, CAS [[946128-88-7]]

Product Overview

• Article Name: Avutometinib, CAS [[946128-88-7]]
• Biozol Catalog Number: FBM-10-4112
• Supplier Catalog Number: 10-4112
• Alternative Catalog Number: FBM-10-4112-5MG, FBM-10-4112-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one. Alternate Names: RO5126766, CH5126766

Product Description

Dual MEK/RAF inhibitor

Product Properties

• Molecular Weight: 471.46
• Purity: >98% by HPLC (NMR Conforms)
• Form: White solid
• CAS Number: [946128-88-7]
• Formula: C21H18FN5O5S

Application Notes

• Application Notes: Avutometinib is a dual MEK/RAF inhibitor (IC50s: MEK = 160 nM, CRAF = 56 nM, BRAF = 19 nM, BRAF V600E = 8nM).1 It directly inhibits unphosphorylated MEK without causing induction of MEK phosphorylation by RAF. The avutemetinib-MEK adduct is a dominant-negative inhibitor of RAF, stabilizing the MEK/RAF complex and locking in an inactive form. Avutometinib displayed efficacy across multiple RAS-mutated cancer cell lines and an SK-MEL-2 xenograft model.2 It displayed synergistic effects with eribulin against triple-negative breast cancer cell lines.3 Avutometinib also displayed efficacy in combination with the FAK inhibitor Defactinib in KRAS-mutated NSCLC cells.4