BI 2536, CAS [[755038-02-9]]

Produktübersicht

• Artikelname: BI 2536, CAS [[755038-02-9]]
• Artikelnummer: FBM-10-4121
• Hersteller Artikelnummer: 10-4121
• Alternativnummer: FBM-10-4121-5MG, FBM-10-4121-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

Produktbeschreibung

Dual Plk/BRD4 inhibitor - Destabilizes Myc

Produkteigenschaften

• Molekulargewicht: 521.67
• Reinheit: 97% by HPLC, NMR (conforms)
• Formulierung: Off-white solid
• CAS Nummer: [755038-02-9]
• Formel: C28H39N7O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: BI 2536 was originally reported as a potent (IC50s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4