BI 2536, CAS [[755038-02-9]]

Product Overview

• Article Name: BI 2536, CAS [[755038-02-9]]
• Biozol Catalog Number: FBM-10-4121
• Supplier Catalog Number: 10-4121
• Alternative Catalog Number: FBM-10-4121-5MG,FBM-10-4121-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Dual Plk/BRD4 inhibitor - Destabilizes Myc

Product Properties

• Molecular Weight: 521.67
• Purity: 97% by HPLC, NMR (conforms)
• Form: Off-white solid
• CAS Number: [755038-02-9]
• Formula: C28H39N7O3

Application Notes

• Application Notes: BI 2536 was originally reported as a potent (IC50s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4