LY2603618, CAS [[911222-45-2]]

Produktübersicht

• Artikelname: LY2603618, CAS [[911222-45-2]]
• Artikelnummer: FBM-10-4123
• Hersteller Artikelnummer: 10-4123
• Alternativnummer: FBM-10-4123-5MG, FBM-10-4123-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N-(5-methyl-2-pyrazinyl)urea. Alternate Names: Rabusertib

Produktbeschreibung

Chk1 inhibitor

Produkteigenschaften

• Molekulargewicht: 436.30
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [911222-45-2]
• Formel: C18H22BrN5O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response - combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5