LY2603618, CAS [[911222-45-2]]

Product Overview

• Article Name: LY2603618, CAS [[911222-45-2]]
• Biozol Catalog Number: FBM-10-4123
• Supplier Catalog Number: 10-4123
• Alternative Catalog Number: FBM-10-4123-5MG, FBM-10-4123-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N-(5-methyl-2-pyrazinyl)urea. Alternate Names: Rabusertib

Product Description

Chk1 inhibitor

Product Properties

• Molecular Weight: 436.30
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [911222-45-2]
• Formula: C18H22BrN5O3

Application Notes

• Application Notes: LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response - combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5