H-151, CAS [[941987-60-6]]

Produktübersicht

• Artikelname: H-151, CAS [[941987-60-6]]
• Artikelnummer: FBM-10-4132
• Hersteller Artikelnummer: 10-4132
• Alternativnummer: FBM-10-4132-10MG, FBM-10-4132-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(4-Ethylphenyl)-N-1H-indol-3-yl urea

Produktbeschreibung

STING antagonist

Produkteigenschaften

• Molekulargewicht: 279.34
• Reinheit: 98%, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [941987-60-6]
• Formel: C17H17N3O

Anwendungsbeschreibung

• Anwendungsbeschreibung: H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.1 H-151 alleviates microglial dysfunction and a broad spectrum of Alzheimers disease pathologies in AD mouse models.3