H-151, CAS [[941987-60-6]]

Product Overview

• Article Name: H-151, CAS [[941987-60-6]]
• Biozol Catalog Number: FBM-10-4132
• Supplier Catalog Number: 10-4132
• Alternative Catalog Number: FBM-10-4132-10MG, FBM-10-4132-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(4-Ethylphenyl)-N-1H-indol-3-yl urea

Product Description

STING antagonist

Product Properties

• Molecular Weight: 279.34
• Purity: 98%, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [941987-60-6]
• Formula: C17H17N3O

Application Notes

• Application Notes: H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.1 H-151 alleviates microglial dysfunction and a broad spectrum of Alzheimers disease pathologies in AD mouse models.3