GNS561, CAS [[1914148-73-4]]

Produktübersicht

• Artikelname: GNS561, CAS [[1914148-73-4]]
• Artikelnummer: FBM-10-4138
• Hersteller Artikelnummer: 10-4138
• Alternativnummer: FBM-10-4138-5MG,FBM-10-4138-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[4-(tert-Butylamino)piperidin-1-yl]-N-[(4-chlorophenyl)methyl]quinoline-2-amine hydrochloride. Alternate Names: Ezurpimtrostat HCl

Produktbeschreibung

PPT1 inhibitor/STING activator

Produkteigenschaften

• Molekulargewicht: 459.46
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [1914148-73-4]
• Formel: C25H31ClN4HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: GNS561 induces lysosomal dysregulation leading to inhibition of autophagy.1 It displayed efficacy against intrahepatic cholangiocarcinoma1 and hepatocellular carcinoma2. GNS561 acted as an anti-fibrotic agent against liver fibrosis in a rat model.3 GNS561-induced cell death is partially caused by inhibition of palmitoyl-protein thioesterase 1 (PPT1) leading to lysosomal dysfunction.4 GNS561 treatment of prostate and ovarian cancer models enhanced STING expression and activation via PPT1 inhibition leading to infiltration of cytotoxic T cells.5 GNS561 represents a potentially novel immunotherapy for cold tumors.

Bilder

10-4138