GNS561, CAS [[1914148-73-4]]

Product Overview

• Article Name: GNS561, CAS [[1914148-73-4]]
• Biozol Catalog Number: FBM-10-4138
• Supplier Catalog Number: 10-4138
• Alternative Catalog Number: FBM-10-4138-5MG, FBM-10-4138-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[4-(tert-Butylamino)piperidin-1-yl]-N-[(4-chlorophenyl)methyl]quinoline-2-amine hydrochloride. Alternate Names: Ezurpimtrostat HCl

Product Description

PPT1 inhibitor/STING activator

Product Properties

• Molecular Weight: 459.46
• Purity: >98% by HPLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [1914148-73-4]
• Formula: C25H31ClN4HCl

Application Notes

• Application Notes: GNS561 induces lysosomal dysregulation leading to inhibition of autophagy.1 It displayed efficacy against intrahepatic cholangiocarcinoma1 and hepatocellular carcinoma2. GNS561 acted as an anti-fibrotic agent against liver fibrosis in a rat model.3 GNS561-induced cell death is partially caused by inhibition of palmitoyl-protein thioesterase 1 (PPT1) leading to lysosomal dysfunction.4 GNS561 treatment of prostate and ovarian cancer models enhanced STING expression and activation via PPT1 inhibition leading to infiltration of cytotoxic T cells.5 GNS561 represents a potentially novel immunotherapy for cold tumors.