PRIMA-1MET, CAS [[5291-32-7]]

Produktübersicht

• Artikelname: PRIMA-1MET, CAS [[5291-32-7]]
• Artikelnummer: FBM-10-4175
• Hersteller Artikelnummer: 10-4175
• Alternativnummer: FBM-10-4175-5MG, FBM-10-4175-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one. Alternate Names: APR-246

Produktbeschreibung

Reactivates mutant p53

Produkteigenschaften

• Molekulargewicht: 199.25
• Reinheit: 95%, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [5291-32-7]
• Formel: C10H17NO3

Anwendungsbeschreibung

• Anwendungsbeschreibung: PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8