PRIMA-1MET, CAS [[5291-32-7]]

Product Overview

• Article Name: PRIMA-1MET, CAS [[5291-32-7]]
• Biozol Catalog Number: FBM-10-4175
• Supplier Catalog Number: 10-4175
• Alternative Catalog Number: FBM-10-4175-5MG, FBM-10-4175-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one. Alternate Names: APR-246

Product Description

Reactivates mutant p53

Product Properties

• Molecular Weight: 199.25
• Purity: 95%, NMR (Conforms)
• Form: White solid
• CAS Number: [5291-32-7]
• Formula: C10H17NO3

Application Notes

• Application Notes: PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8