XI-011, CAS [[59474-01-0]]

Produktübersicht

• Artikelname: XI-011, CAS [[59474-01-0]]
• Artikelnummer: FBM-10-4177
• Hersteller Artikelnummer: 10-4177
• Alternativnummer: FBM-10-4177-5MG, FBM-10-4177-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (10-Methylanthracen-9-yl)methyl carbimidothioate hydrochloride. Alternate Names: NSC146109

Produktbeschreibung

p53 activator / MDM4 inhibitor

Produkteigenschaften

• Molekulargewicht: 316.85
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [59474-01-0]
• Formel: C17H16N2SHCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: XI-011 activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX).1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4