XI-011, CAS [[59474-01-0]]

Product Overview

• Article Name: XI-011, CAS [[59474-01-0]]
• Biozol Catalog Number: FBM-10-4177
• Supplier Catalog Number: 10-4177
• Alternative Catalog Number: FBM-10-4177-5MG,FBM-10-4177-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: NSC146109

Product Description

p53 activator / MDM4 inhibitor

Product Properties

• Molecular Weight: 316.85
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [59474-01-0]
• Formula: C17H16N2SHCl

Application Notes

• Application Notes: XI-011 activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX).1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4