S1RA, CAS [[1265917-14-3]]

Produktübersicht

• Artikelname: S1RA, CAS [[1265917-14-3]]
• Artikelnummer: FBM-10-4201
• Hersteller Artikelnummer: 10-4201
• Alternativnummer: FBM-10-4201-5MG, FBM-10-4201-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-{2-[5-Methyl-1-(napthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride. Alternate Names: E-52862 HCl

Produktbeschreibung

Sigma-1 antagonist

Produkteigenschaften

• Molekulargewicht: 373.88
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1265917-14-3]
• Formel: C20H23N3O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: S1RA (E-52862) is a potent and selective 1 antagonist with weak binding at 2 (IC50s: 1 = 17nM, 2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a 1 dependent manner.3 BD1063 potentiated µ-opioid antinociception in mice in a -dependent manner.4 S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5