S1RA, CAS [[1265917-14-3]]

Product Overview

• Article Name: S1RA, CAS [[1265917-14-3]]
• Biozol Catalog Number: FBM-10-4201
• Supplier Catalog Number: 10-4201
• Alternative Catalog Number: FBM-10-4201-5MG, FBM-10-4201-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-{2-[5-Methyl-1-(napthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride. Alternate Names: E-52862 HCl

Product Description

Sigma-1 antagonist

Product Properties

• Molecular Weight: 373.88
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1265917-14-3]
• Formula: C20H23N3O2HCl

Application Notes

• Application Notes: S1RA (E-52862) is a potent and selective 1 antagonist with weak binding at 2 (IC50s: 1 = 17nM, 2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a 1 dependent manner.3 BD1063 potentiated µ-opioid antinociception in mice in a -dependent manner.4 S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5