VER-246608, CAS [[1684386-71-7]]

Produktübersicht

• Artikelname: VER-246608, CAS [[1684386-71-7]]
• Artikelnummer: FBM-10-4224
• Hersteller Artikelnummer: 10-4224
• Alternativnummer: FBM-10-4224-5MG, FBM-10-4224-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxybenzamide

Produktbeschreibung

Pan-PDK inhibitor

Produkteigenschaften

• Molekulargewicht: 552.96
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [1684386-71-7]
• Formel: C28H23ClF2N4O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: VER-246608 is a potent (IC50s: PDK-1 = 35 nM, PDK-2 = 84 nM, PDK-3 = 40 nM, PDK-4 = 91 nM) and selective pan-pyruvate dehydrogenase kinase inhibitor.1 It decreased oxygen consumption and attenuated glycolytic activity (Warburg metabolism) under D-glucose/L-glutamine-depleted conditions. VER-246608 treatment of four cancer lines (PC-3, SW-1088, UM-22B, and MEF) under depleted D-glucose/L-glutamine conditions resulted in almost complete inhibition of cell growth. It also acted synergistically with doxorubicin in PC-3 and ES-2 cells.