VER-246608, CAS [[1684386-71-7]]

Product Overview

• Article Name: VER-246608, CAS [[1684386-71-7]]
• Biozol Catalog Number: FBM-10-4224
• Supplier Catalog Number: 10-4224
• Alternative Catalog Number: FBM-10-4224-5MG,FBM-10-4224-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Pan-PDK inhibitor

Product Properties

• Molecular Weight: 552.96
• Purity: >98% by HPLC NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [1684386-71-7]
• Formula: C28H23ClF2N4O4

Application Notes

• Application Notes: VER-246608 is a potent (IC50s: PDK-1 = 35 nM, PDK-2 = 84 nM, PDK-3 = 40 nM, PDK-4 = 91 nM) and selective pan-pyruvate dehydrogenase kinase inhibitor.1 It decreased oxygen consumption and attenuated glycolytic activity (Warburg metabolism) under D-glucose/L-glutamine-depleted conditions. VER-246608 treatment of four cancer lines (PC-3, SW-1088, UM-22B, and MEF) under depleted D-glucose/L-glutamine conditions resulted in almost complete inhibition of cell growth. It also acted synergistically with doxorubicin in PC-3 and ES-2 cells.