Quinacrine hydrochloride, CAS [[69-05-6]]

Produktübersicht

• Artikelname: Quinacrine hydrochloride, CAS [[69-05-6]]
• Artikelnummer: FBM-10-4251
• Hersteller Artikelnummer: 10-4251
• Alternativnummer: FBM-10-4251-20MG, FBM-10-4251-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride

Produktbeschreibung

Antiprotozoan / Anticancer

Produkteigenschaften

• Molekulargewicht: 472.88
• Reinheit: 98% by HPLC, NMR (Confirms)
• Formulierung: Yellow solid
• CAS Nummer: [69-05-6]
• Formel: C23H30ClN3O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5