Quinacrine hydrochloride, CAS [[69-05-6]]

Product Overview

• Article Name: Quinacrine hydrochloride, CAS [[69-05-6]]
• Biozol Catalog Number: FBM-10-4251
• Supplier Catalog Number: 10-4251
• Alternative Catalog Number: FBM-10-4251-20MG, FBM-10-4251-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride

Product Description

Antiprotozoan / Anticancer

Product Properties

• Molecular Weight: 472.88
• Purity: 98% by HPLC, NMR (Confirms)
• Form: Yellow solid
• CAS Number: [69-05-6]
• Formula: C23H30ClN3O2HCl

Application Notes

• Application Notes: Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5