TP-040, CAS [[2757254-99-0]]

Produktübersicht

• Artikelname: TP-040, CAS [[2757254-99-0]]
• Artikelnummer: FBM-10-4289
• Hersteller Artikelnummer: 10-4289
• Alternativnummer: FBM-10-4289-5MG, FBM-10-4289-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-((1-Methyl-1H-imidazol-4-yl)methyl)-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine. Alternate Names: O-GlcNAcase-IN-1

Produktbeschreibung

O-GlcNAcase inhibitor

Produkteigenschaften

• Molekulargewicht: 286.38
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [2757254-99-0]
• Formel: C15H22N6

Anwendungsbeschreibung

• Anwendungsbeschreibung: TP-040 is a potent and brain-penetrant inhibitor (IC50 = 46 nM) of O-GlcNAcase (OGA). OGA catalyzes the cleavage of O-linked N-acetylglucosamine from serine and threonine residues. On tau proteins, this leads to a less soluble and less stable protein form that is prone to aggregation. TP-040 is an interesting new tool for studying the effects of tau protein aggregation in neurodegenerative diseases.