Chemical Name: N-((1-Methyl-1H-imidazol-4-yl)methyl)-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine. Alternate Names: O-GlcNAcase-IN-1
O-GlcNAcase inhibitor
Molecular Weight:
286.38
Purity:
>98% by HPLC, NMR (Conforms)
Form:
White to off-white solid
CAS Number:
[2757254-99-0]
Formula:
C15H22N6
Application Notes:
TP-040 is a potent and brain-penetrant inhibitor (IC50 = 46 nM) of O-GlcNAcase (OGA). OGA catalyzes the cleavage of O-linked N-acetylglucosamine from serine and threonine residues. On tau proteins, this leads to a less soluble and less stable protein form that is prone to aggregation. TP-040 is an interesting new tool for studying the effects of tau protein aggregation in neurodegenerative diseases.
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