NGI-189, CAS [[2763063-26-7]]

Produktübersicht

• Artikelname: NGI-189, CAS [[2763063-26-7]]
• Artikelnummer: FBM-10-4292
• Hersteller Artikelnummer: 10-4292
• Alternativnummer: FBM-10-4292-5MG,FBM-10-4292-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Oligosaccharyltransferase inhibitor

Produkteigenschaften

• Molekulargewicht: 478.63
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [2763063-26-7]
• Formel: C22H30N4O4S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: NGI-189 is a second generation (NGI-1) oligosaccharyltransferase (OST) inhibitor (IC50 = 90 nM) with preference for OST-A over OST-B. It prevented N-glycosylation of EGFR mutant NSCLC cells and was tolerated in vivo. NGI-189 prevented tumor growth in YU-006 and YU-101 NSCLC tumor xenograft models.