NGI-189, CAS [[2763063-26-7]]

Product Overview

• Article Name: NGI-189, CAS [[2763063-26-7]]
• Biozol Catalog Number: FBM-10-4292
• Supplier Catalog Number: 10-4292
• Alternative Catalog Number: FBM-10-4292-5MG,FBM-10-4292-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Oligosaccharyltransferase inhibitor

Product Properties

• Molecular Weight: 478.63
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2763063-26-7]
• Formula: C22H30N4O4S2

Application Notes

• Application Notes: NGI-189 is a second generation (NGI-1) oligosaccharyltransferase (OST) inhibitor (IC50 = 90 nM) with preference for OST-A over OST-B. It prevented N-glycosylation of EGFR mutant NSCLC cells and was tolerated in vivo. NGI-189 prevented tumor growth in YU-006 and YU-101 NSCLC tumor xenograft models.