BI 749327, CAS [[2361241-23-6]]

Produktübersicht

• Artikelname: BI 749327, CAS [[2361241-23-6]]
• Artikelnummer: FBM-10-4318
• Hersteller Artikelnummer: 10-4318
• Alternativnummer: FBM-10-4318-5MG,FBM-10-4318-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Selective TRPC6 antagonist

Produkteigenschaften

• Molekulargewicht: 442.44
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2361241-23-6]
• Formel: C23H21F3N4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models. BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2