BI 749327, CAS [[2361241-23-6]]

Product Overview

• Article Name: BI 749327, CAS [[2361241-23-6]]
• Biozol Catalog Number: FBM-10-4318
• Supplier Catalog Number: 10-4318
• Alternative Catalog Number: FBM-10-4318-5MG,FBM-10-4318-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Selective TRPC6 antagonist

Product Properties

• Molecular Weight: 442.44
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [2361241-23-6]
• Formula: C23H21F3N4O2

Application Notes

• Application Notes: Potent (IC50 = 13 nM mouse TRPC6, 19 nM human TRPC6) and selective (85-fold over TRPC3, 42-fold over TRC7) orally available blocker of TRPC6.1 It suppressed interstitial fibrosis and associated molecular signaling in mouse heart and kidney disease models. BI 749327 reversed established pulmonary hypertension by 50% via regression of pulmonary remodeling in a mouse model.2