Chemical Name: N-(2,6-Dichloro-4-pyridinyl)-N-[2-fluoro-3-(trifluoromethyl)phenyl]urea
Septin inhibitor
Molekulargewicht:
368.11
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[2456263-31-1]
Formel:
C13H7Cl2F4N3O
Anwendungsbeschreibung:
UR214-9 is an analog of Forchlorfenuron that was found to reduce HER2 and human epididymis protein 4 (HE4) levels and showed cytotoxicity against endometrial cancer via septin inhibition.1,2 It reduced ocular hypertension via disruption of the septin filament assembly in mice.3 UR214-9 induced mitochondrial fragmentation in macrophages in zebrafish larvae without altering mitochondrial mass leading to lytic cell death.4
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