Chemical Name: N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
Selective inhibitor of TAM kinases
Molekulargewicht:
560.56
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[1361030-48-9]
Formel:
C30H26F2N4O5
Anwendungsbeschreibung:
LDC1267 is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It was able to activate the innate immune system and enhance NK killer cell activity to kill cancer metastases in vivo.
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