PZL-A, CAS [[3068830-89-4]]

Produktübersicht

• Artikelname: PZL-A, CAS [[3068830-89-4]]
• Artikelnummer: FBM-10-4421
• Hersteller Artikelnummer: 10-4421
• Alternativnummer: FBM-10-4421-1MG, FBM-10-4421-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-[(4S)-8-Chloro-3,4-dihydro-2H-chromen-4-yl]-3-(1-phenylpyrazol-3-yl)urea, (S)-1-(8-chlorochroman-4-yl)-3-(1-phenyl-1H-pyrazol-3-yl)urea

Produktbeschreibung

mtDNA activator

Produkteigenschaften

• Molekulargewicht: 368.82
• Reinheit: >97% by HPLC NMR (Conforms)
• Formulierung: Off-white to pale yellow solid
• CAS Nummer: [3068830-89-4]
• Formel: C19H17ClN4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: PZL-A is a first-in-class activator of mammalian mitochondrial DNA (mtDNA). AC50s: 160 nM for A467T mutant, 20 nM for G848S mutant. mtDNA, which encodes essential protein subunits of the oxidative phosphorylation complexes, is replicated by DNA polymerase POLgamma. PZL-A restores function to mutant POLgamma via binding to an allosteric site between the catalytic subunits POLgammaA and POLgammaB. An important new tool for studying mitochondrial disorders.