PZL-A, CAS [[3068830-89-4]]

Product Overview

• Article Name: PZL-A, CAS [[3068830-89-4]]
• Biozol Catalog Number: FBM-10-4421
• Supplier Catalog Number: 10-4421
• Alternative Catalog Number: FBM-10-4421-1MG, FBM-10-4421-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[(4S)-8-Chloro-3,4-dihydro-2H-chromen-4-yl]-3-(1-phenylpyrazol-3-yl)urea, (S)-1-(8-chlorochroman-4-yl)-3-(1-phenyl-1H-pyrazol-3-yl)urea

Product Description

mtDNA activator

Product Properties

• Molecular Weight: 368.82
• Purity: >97% by HPLC NMR (Conforms)
• Form: Off-white to pale yellow solid
• CAS Number: [3068830-89-4]
• Formula: C19H17ClN4O2

Application Notes

• Application Notes: PZL-A is a first-in-class activator of mammalian mitochondrial DNA (mtDNA). AC50s: 160 nM for A467T mutant, 20 nM for G848S mutant. mtDNA, which encodes essential protein subunits of the oxidative phosphorylation complexes, is replicated by DNA polymerase POLgamma. PZL-A restores function to mutant POLgamma via binding to an allosteric site between the catalytic subunits POLgammaA and POLgammaB. An important new tool for studying mitochondrial disorders.