Chemical Name: t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate
Autophagy blocker GRAMD1A inhibition
Molekulargewicht:
417.53
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[2375541-45-8]
Formel:
C21H27N3O4S
Anwendungsbeschreibung:
Autogramin-2 is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM, Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A). Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
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